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  • 李江,袁士杰,聂明明*.上皮间质转化相关长链非编码RNA与胃癌的关系[J].第二军医大学学报,2019,40(2):209-212    [点击复制]
  • LI Jiang,YUAN Shi-jie,NIE Ming-ming*.Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer[J].Acad J Sec Mil Med Univ,2019,40(2):209-212   [点击复制]
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上皮间质转化相关长链非编码RNA与胃癌的关系
李江,袁士杰,聂明明*
0
(海军军医大学(第二军医大学)长海医院普通外科, 上海 200433
*通信作者)
摘要:
胃癌是威胁人类健康的主要恶性肿瘤之一,其发生涉及多步骤、多基因的相互作用过程。上皮间质转化(EMT)是上皮细胞通过特定程序转化为有间质表型细胞的过程。研究表明长链非编码RNA(lncRNA)可以通过与靶蛋白结合、作为竞争性内源RNA竞争微RNA等方式促进或抑制EMT过程,且许多特异表达的EMT相关lncRNA与胃癌的侵袭、转移密切相关。本文主要就EMT相关lncRNA在胃癌侵袭和转移中的调控机制作一综述。
关键词:  上皮间质转化  长链非编码RNA  胃肿瘤  肿瘤侵袭  肿瘤转移
DOI:10.16781/j.0258-879x.2019.02.0209
投稿时间:2018-07-15修订日期:2018-09-18
基金项目:国家自然科学基金(81472277).
Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer
LI Jiang,YUAN Shi-jie,NIE Ming-ming*
(Department of General Surgery, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Gastric cancer is one of the main malignancies threatening human health, and its occurrence involves multistep and multigene interactions. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform to mesenchymal phenotypic cells through specific procedures. Studies have shown that long non-coding RNAs (lncRNAs) can promote or inhibit EMT by binding to target proteins and competing microRNAs as competitive endogenous RNAs, and some specific EMT-related lncRNAs are deeply involved in the invasion and metastasis of gastric cancer. In this review, we summarized the recent mechanisms of EMT-related lncRNAs in the regulating the invasion and metastasis of gastric cancer.
Key words:  epithelial-mesenchymal transition  long non-coding RNA  stomach neoplasms  neoplasm invasiveness  neoplasm metastasis