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  • 徐汝明,顾颖,杨帆,王国坤.微粒在动脉粥样硬化发生和发展中的作用[J].第二军医大学学报,2019,40(4):430-434    [点击复制]
  • XU Ru-ming,GU Ying,YANG Fan,WANG Guo-kun.Role of microparticles in development and progression of atherosclerosis[J].Acad J Sec Mil Med Univ,2019,40(4):430-434   [点击复制]
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微粒在动脉粥样硬化发生和发展中的作用
徐汝明1,顾颖1,杨帆2,王国坤2*
0
(1. 海军军医大学(第二军医大学)长海医院心血管内科, 上海 200433;
2. 海军军医大学(第二军医大学)长海医院心血管外科, 上海 200433
*通信作者)
摘要:
微粒是细胞激活或凋亡时细胞膜通过出芽形式脱落的直径约为0.1~1 μm的小囊泡,载有蛋白质、细胞因子、mRNA、微RNA等物质,发挥多种生物学效应。在动脉粥样硬化的发生和发展中,微粒在内皮细胞损伤、炎症反应、平滑肌细胞增殖和迁移等过程中发挥重要作用。循环中高水平的微粒不仅是动脉粥样硬化患者血管损伤的生物标志物,也是动脉粥样硬化的潜在诊断指标和治疗靶点。本文立足于微粒在动脉粥样硬化发生和发展中的作用,从细胞水平对相关研究进展作一综述。
关键词:  微粒  动脉粥样硬化  内皮细胞  炎症  平滑肌细胞
DOI:10.16781/j.0258-879x.2019.04.0430
投稿时间:2018-10-12修订日期:2018-12-06
基金项目:
Role of microparticles in development and progression of atherosclerosis
XU Ru-ming1,GU Ying1,YANG Fan2,WANG Guo-kun2*
(1. Department of Cardiovasology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Cardiovascular Surgery, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Microparticles are small vesicles with a diameter ranging from 0.1 to 1 μm that fall off from cell membranes through germination when cells are activated or apoptotic. Microparticle contains proteins, cytokines, mRNA, microRNA and other substances, and exerts a variety of biological functions. Microparticle plays an important role in endothelial cell dysfunction, inflammation, and smooth muscle cell proliferation and migration in the development and progression of atherosclerosis. High-level microparticles in circulation are not only biomarkers of vascular injury in atherosclerosis patients, but also potential diagnostic and therapeutic targets of atherosclerosis. This review focuses on the role of microparticle in the development and progression of atherosclerosis, and sums up the related research progresses at the cellular level.
Key words:  microparticles  atherosclerosis  endothelial cells  inflammation  smooth muscle myocytes