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  • 王骐榕,李新方,杨峰.磁共振含钆造影剂脑沉积的现状及进展[J].第二军医大学学报,2018,39(11):1255-1258    [点击复制]
  • WANG Qi-rong,LI Xin-fang,YANG Feng.Magnetic resonance gadolinium-based contrast agent deposition in brain: status and progress[J].Acad J Sec Mil Med Univ,2018,39(11):1255-1258   [点击复制]
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磁共振含钆造影剂脑沉积的现状及进展
王骐榕1,2,李新方1,杨峰1*
0
(1. 海军军医大学(第二军医大学)药学院无机化学教研室, 上海 200433;
2. 上海海淞医院呼吸内科, 上海 200940
*通信作者)
摘要:
含钆造影剂是目前临床应用最广泛的磁共振造影剂,近年来大量证据表明脑深部核团的磁共振信号改变与重复注射含钆造影剂有关,尤其是在齿状核和苍白球组织,钆沉积现象最为明显。本文主要综述了含钆造影剂脑部沉积现象的研究现状,分析了脑部钆沉积与含钆造影剂类型的关系,并对相关政策进展进行介绍。
关键词:  含钆造影剂  脑沉积  磁共振成像  苍白球  齿状核
DOI:10.16781/j.0258-879x.2018.11.1255
投稿时间:2018-04-02修订日期:2018-05-11
基金项目:上海市自然科学基金(16ZR1444200).
Magnetic resonance gadolinium-based contrast agent deposition in brain: status and progress
WANG Qi-rong1,2,LI Xin-fang1,YANG Feng1*
(1. Department of Inorganic Chemistry, School of Pharmacy, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Respiratory Medicine, Shanghai Haisong Hospital, Shanghai 200940, China
*Corresponding author)
Abstract:
Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging. Recently, a large amount of evidence indicates that change of magnetic resonance signal in deep brain nuclei is related to repeated injection of GBCAs. Especially in the dentatum and pallidum the gadolinium deposition is most obvious. This paper reviews the research status and policy progress of brain deposition of GBCAs, and introduces the relationship between gadolinium deposition in the brain and the type of GBCAs.
Key words:  gadolinium-based contrast agents  deposition in brain  magnetic resonance imaging  globus pallidus  dentate nucleus