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  • 张红军,赵世红.视网膜黄斑区神经节细胞复合体厚度检测的研究进展[J].第二军医大学学报,2018,39(4):417-421    [点击复制]
  • ZHANG Hong-jun,ZHAO Shi-hong.Progress in the detection of macular ganglion cell complex thickness[J].Acad J Sec Mil Med Univ,2018,39(4):417-421   [点击复制]
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视网膜黄斑区神经节细胞复合体厚度检测的研究进展
张红军,赵世红*
0
(海军军医大学(第二军医大学)长海医院眼科, 上海 200433
*通信作者)
摘要:
视网膜神经节细胞与视功能密切相关。大多致盲性眼病如原发性青光眼、视神经炎、糖尿病性视网膜病变、萎缩型年龄相关性黄斑变性等均存在视网膜神经节细胞凋亡及其轴突的损害。神经节细胞主要存在于黄斑区的视网膜神经纤维层、神经节细胞层、内丛状层结构中,此3层结构统称为视网膜神经节细胞复合体,其厚度变化可用于反映视网膜神经节细胞状况。研究发现视网膜神经节细胞受损会出现神经节细胞复合体厚度变薄,因此观察视网膜神经节细胞复合体厚度变化对诊断相关眼病、了解病情严重程度及判断预后有重要意义。本文就视网膜黄斑区神经节细胞复合体厚度检测在多种眼病中的研究进展进行综述,为相关眼病的早期诊断、防治及判断预后提供帮助。
关键词:  视网膜神经节细胞  黄斑  原发性青光眼  视神经炎  糖尿病性视网膜病变  年龄相关性黄斑变性
DOI:10.16781/j.0258-879x.2018.04.0417
投稿时间:2018-01-11修订日期:2018-04-02
基金项目:
Progress in the detection of macular ganglion cell complex thickness
ZHANG Hong-jun,ZHAO Shi-hong*
(Department of Ophthalmology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Retinal ganglion cells are closely related to visual function. Retinal ganglion cell apoptosis and axonal injury can be found in many blinding eye diseases, such as primary glaucoma, optic neuritis, diabetic retinopathy, and atrophic age-related macular degeneration. Ganglion cells mainly exist in the retinal nerve fiber layer, the ganglion cell layer and the inner plexiform layer of the macular area. These three structures are collectively referred to as the retinal ganglion cell complex, and change of the thickness reflects the state of the retinal ganglion cell. It has been reported that ganglion cell complex thickness is thinner in the injured retinal ganglion cells. Therefore it is important to detected thickness of retinal ganglion cell complex in the diagnosis of ocular disease and the evaluation of its severity and prognosis. In this paper, we reviewed the recent progress in the detection of retinal ganglion cell complex thickness in various eye diseases to assist the early diagnosis, treatment and evaluating prognosis of associated ophthalmopathy.
Key words:  retinal ganglion cell  macula lutea  primary glaucoma  optic neuritis  diabetic retinopathy  age-related macular degeneration