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  • 周晶晶,李家速,王奇金*.Omega-3多不饱和脂肪酸对脂肪代谢调节作用研究进展[J].第二军医大学学报,2019,40(1):68-73    [点击复制]
  • ZHOU Jing-jing,LI Jia-su,WANG Qi-jin*.Advances in regulation of omega-3 polyunsaturated fatty acids on fat metabolism[J].Acad J Sec Mil Med Univ,2019,40(1):68-73   [点击复制]
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Omega-3多不饱和脂肪酸对脂肪代谢调节作用研究进展
周晶晶,李家速,王奇金*
0
(海军军医大学(第二军医大学)长海医院内分泌科, 上海 200433
*通信作者)
摘要:
肥胖是2型糖尿病、心血管病和多种癌症的危险因素,其防治形势十分严峻。Omega-3多不饱和脂肪酸(n-3 PUFA)是一种从深海鱼类中提取出来的多不饱和脂肪酸,具有显著的抗炎和降低三酰甘油的作用,但其抗肥胖作用仍有争议。在动物模型中发现,n-3 PUFA可以有效降低脂肪含量;然而人体研究却表明n-3 PUFA可能无助于减肥,但可能会减少体质量进一步增加。n-3 PUFA可通过调节肠道菌群、调节脂质代谢、抑制食欲、缓解脂肪组织炎症和表观遗传改变等机制改善与肥胖相关的代谢变化,从而在肥胖与其相关代谢性疾病的防治中发挥重要作用。
关键词:  肥胖症  代谢综合征  ω-3脂肪酸类  脂类  炎症
DOI:10.16781/j.0258-879x.2019.01.0068
投稿时间:2018-05-31修订日期:2019-01-11
基金项目:国家自然科学基金(81670741),长海医院"1255"学科建设计划科研创新探索项目(CH125541900).
Advances in regulation of omega-3 polyunsaturated fatty acids on fat metabolism
ZHOU Jing-jing,LI Jia-su,WANG Qi-jin*
(Department of Endocrinology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Obesity is a risk factor for type 2 diabetes, cardiovascular diseases, and various cancers. The prevention and treatment of obesity have become the focus of public health. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are polyunsaturated fatty acids extracted from deep-sea fish. The anti-inflammatory and triglyceride-lowering properties of n-3 PUFA are well known, but its role in the treatment of obesity is still controversial. In animal models, n-3 PUFA can effectively reduce fat. However, in humans, existing studies have shown that n-3 PUFA may not contribute to weight loss, but may slow down weight gain. N-3 PUFA can improve the metabolic changes associated with obesity by regulating intestinal flora, regulating lipid metabolism, suppressing appetite, alleviating adipose tissue inflammation and altering epigenetic mechanisms, thus playing an important role in the prevention and treatment of obesity and the related metabolic diseases.
Key words:  obesity  metabolic syndrome  omega-3 fatty acids  lipids  inflammation