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  • 万仁辉,翟骁,鲁瑾,王奇金.嗜黏蛋白阿克曼菌与肥胖的关系[J].第二军医大学学报,2019,40(2):203-208    [点击复制]
  • WAN Ren-hui,ZHAI Xiao,LU Jin,WANG Qi-jin.Relationship between Akkermansia muciniphila and obesity[J].Acad J Sec Mil Med Univ,2019,40(2):203-208   [点击复制]
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嗜黏蛋白阿克曼菌与肥胖的关系
万仁辉1,翟骁2,鲁瑾1,王奇金1*
0
(1. 海军军医大学(第二军医大学)长海医院内分泌科, 上海 200433;
2. 海军军医大学(第二军医大学)长海医院骨科, 上海 200433
*通信作者)
摘要:
嗜黏蛋白阿克曼菌(A.muciniphila)是一种人类肠道的正常菌群,肥胖患者肠道菌群中的A.muciniphila丰度明显降低。许多证据表明A.muciniphila与肥胖、糖尿病、心血管疾病和低度炎症呈负相关。A.muciniphila不仅可以保护肠道上皮细胞及黏液层的完整性发挥代谢保护作用,在炎症反应过程中A.muciniphila也能通过调节性T细胞、内源性大麻素系统以及非经典Toll样受体发挥抗炎作用。本文就A.muciniphila与肥胖的相关性及分子机制、临床应用等作一综述。
关键词:  嗜黏蛋白阿克曼菌  肥胖症  代谢综合征  肠道菌群
DOI:10.16781/j.0258-879x.2019.02.0203
投稿时间:2018-06-02修订日期:2019-01-02
基金项目:国家自然科学基金(81670741).
Relationship between Akkermansia muciniphila and obesity
WAN Ren-hui1,ZHAI Xiao2,LU Jin1,WANG Qi-jin1*
(1. Department of Endocrinology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Orthopaedics, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Akkermansia muciniphila (A. muciniphila) is a normal flora of human gastrointestinal tract. The A. muciniphila abundance of intestinal flora in obese patients is significantly decreased. Many evidences suggest that A. muciniphila is negatively related to obesity, diabetes, cardiovascular diseases and low-grade inflammation. A. muciniphila not only plays a metabolic protective role by protecting the integrity of intestinal epithelial cells and mucus layer, but also plays an anti-inflammatory role by regulatory T cells, endogenous cannabinoid system and non-classical Toll-like receptor in the process of inflammatory reaction. This article reviews the relationship between A. muciniphila and obesity, and the molecular mechanism and application of A. muciniphila in obesity.
Key words:  Akkermansia muciniphila  obesity  metabolic syndrome  intestinal bacteria