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  • 王春晖,侯立军*.冲击波致伤时神经-内分泌-炎症系统改变的研究进展[J].第二军医大学学报,2020,41(5):551-557    [点击复制]
  • WANG Chun-hui,HOU Li-jun*.Changes of neuro-endocrine-inflammation system in blast wave injury: recent progress[J].Acad J Sec Mil Med Univ,2020,41(5):551-557   [点击复制]
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冲击波致伤时神经-内分泌-炎症系统改变的研究进展
王春晖,侯立军*
0
(海军军医大学(第二军医大学)长征医院神经外科, 上海 200003
*通信作者)
摘要:
冲击波可刺激机体交感和副交感神经系统,导致自主神经功能改变;也可损伤下丘脑和垂体,激活下丘脑-垂体-靶腺轴和蓝斑-交感神经-肾上腺髓质轴,引起机体内分泌水平改变;此外还可以激活炎症细胞,合成和释放不同的炎症介质,造成机体炎症反应的改变。本文就冲击波致伤时机体自主神经功能、内分泌水平和炎症反应的改变及相互作用进行综述,阐释冲击波的致伤机制,为冲击伤的救治研究提供参考。
关键词:  冲击波  爆震伤  自主神经  内分泌  炎症反应
DOI:10.16781/j.0258-879x.2020.05.0551
投稿时间:2019-11-06修订日期:2020-01-21
基金项目:
Changes of neuro-endocrine-inflammation system in blast wave injury: recent progress
WANG Chun-hui,HOU Li-jun*
(Department of Neurosurgery, Changzheng Hospital, Naval Medical University(Second Military Medical University), Shanghai 200003, China
*Corresponding author)
Abstract:
Blast wave can stimulate the sympathetic and parasympathetic nervous system, leading to the changes of autonomic nervous function. It can also damage the hypothalamus and pituitary, and activate the hypothalamic-pituitary-target gland axis and the locus ceruleus-sympathetic-adrenal medulla axis, resulting in the changes of endocrine level. In addition, it can activate inflammatory cells, synthesize and release different inflammatory mediators, resulting in the changes of inflammatory response. This paper reviews the changes and interactions of autonomic nervous function, endocrine level and inflammatory response in blast wave injury, and further explains the injury mechanism of blase wave, providing references for the treatment of blast wave injury.
Key words:  shock wave  blast injuries  autonomic nerve  endocrine  inflammatory response