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  • 孙俊芳,蔡成*.支气管肺发育不良相关性肺动脉高压研究进展[J].第二军医大学学报,2020,41(2):200-205    [点击复制]
  • SUN Jun-fang,CAI Cheng*.Advances in pulmonary hypertension associated with bronchopulmonary dysplasia[J].Acad J Sec Mil Med Univ,2020,41(2):200-205   [点击复制]
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支气管肺发育不良相关性肺动脉高压研究进展
孙俊芳,蔡成*
0
(上海交通大学附属儿童医院新生儿科, 上海 200062
*通信作者)
摘要:
支气管肺发育不良(BPD)是早产儿常见的慢性呼吸系统疾病,严重影响早产儿的存活率及生存质量。肺动脉高压是包括BPD在内的早产儿慢性呼吸系统疾病的常见并发症。研究显示,并发肺动脉高压的BPD患儿的死亡率为14%~38%。尽管BPD相关性肺动脉高压的检查方法众多,但超声心动图检查仍然是主要评估手段。BPD相关性肺动脉高压的发病机制与预防措施仍未完全阐明,深入研究BPD相关性肺动脉高压有利于降低BPD死亡率和改善患儿预后。本文综述了BPD相关性肺动脉高压的高危因素、发病机制、诊断标准、筛查方法及防治措施。
关键词:  支气管肺发育不良  肺动脉高压  早产儿  危险因素  诊断  治疗
DOI:10.16781/j.0258-879x.2020.02.0200
投稿时间:2019-09-27修订日期:2019-11-26
基金项目:国家自然科学基金(81571467),上海交通大学医学院“紧缺专业硕士研究生临床研究能力提升计划”(JQ201803).
Advances in pulmonary hypertension associated with bronchopulmonary dysplasia
SUN Jun-fang,CAI Cheng*
(Department of Neonatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China
*Corresponding author)
Abstract:
Bronchopulmonary dysplasia (BPD) is a common premature chronic respiratory disease affecting the survival rate and the quality of life of premature infants. Pulmonary hypertension is a common complication of neonatal chronic respiratory diseases including BPD. Studies have shown that the mortality rate of BPD-associated pulmonary hypertension was 14%-38%. Although there are many methods to diagnose BPD-associated pulmonary hypertension, echocardiography is the most important one. The pathogenesis and preventive measures of BPD-associated pulmonary hypertension have not been fully elucidated. In-depth study on BPD-associated pulmonary hypertension is beneficial to reduce the mortality and improve the prognosis of children. This paper reviews the risk factors, pathogenesis, diagnosis criteria, screening methods and control measures of BPD-associated pulmonary hypertension.
Key words:  bronchopulmonary dysplasia  pulmonary hypertension  premature infant  risk factors  diagnosis  treatment