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  • 李辰跃,顾操,赵世红*.膜联蛋白A2磷酸化与功能调控研究进展[J].第二军医大学学报,2019,40(2):213-218    [点击复制]
  • LI Chen-yue,GU Cao,ZHAO Shi-hong*.Advance on phosphorylation and function regulation of annexin A2[J].Acad J Sec Mil Med Univ,2019,40(2):213-218   [点击复制]
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膜联蛋白A2磷酸化与功能调控研究进展
李辰跃,顾操,赵世红*
0
(海军军医大学(第二军医大学)长海医院眼科, 上海 200433
*通信作者)
摘要:
膜联蛋白A2(AnxA2)是一种多功能蛋白,通过多种翻译后修饰来调控其复杂的功能。蛋白质磷酸化是目前最受关注的AnxA2翻译后修饰方式,Ser11、Ser25和Tyr23是最主要的3个磷酸化位点。磷酸化对AnxA2功能调控的可能影响一直是热门话题。近年来研究发现在肿瘤细胞外泌体中也存在AnxA2表达,故对AnxA2及其磷酸化的研究也从细胞内拓展至细胞外。AnxA2及其磷酸化的研究在众多临床学科领域也取得了令人瞩目的成果。本文就Ser11、Ser25和Tyr23磷酸化位点对AnxA2功能调控的影响及其在外泌体中的研究进展作一综述。
关键词:  膜联蛋白A2  磷酸化  外泌体  丝氨酸  酪氨酸
DOI:10.16781/j.0258-879x.2019.02.0213
投稿时间:2019-01-14修订日期:2019-02-13
基金项目:国家自然科学基金(81470652).
Advance on phosphorylation and function regulation of annexin A2
LI Chen-yue,GU Cao,ZHAO Shi-hong*
(Department of Ophthalmology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Annexin A2 (AnxA2) is a multifunctional protein and has complex functions regulated by post-translational modifications. Protein phosphorylation is the most popular post-translational modification of AnxA2. Ser11, Ser25 and Tyr23 are the three most important phosphorylation sites. The possible impact of phosphorylation of AnxA2 function regulation has always been a hot topic. Recently, AnxA2 has been found in the exosomes of tumor cells, and the research of AnxA2 and its phosphorylation has been expanded from intracellular to extracellular. Remarkable achievements in the study of AnxA2 and its phosphorylation have been made in many clinical disciplines. This paper reviewed the advances on the impact of phosphorylation of Ser11, Ser25, Tyr23 sites on AnxA2 function regulation and the research about AnxA2 in exosomes.
Key words:  annexin A2  phosphorylation  exosome  serine  tyrosine