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  • 朱健,孙凯强,史建刚*.巨噬细胞与椎间盘退变的研究进展[J].第二军医大学学报,2019,40(12):1350-1355    [点击复制]
  • ZHU Jian,SUN Kai-qiang,SHI Jian-gang*.Advances on macrophages and intervertebral disc degeneration[J].Acad J Sec Mil Med Univ,2019,40(12):1350-1355   [点击复制]
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巨噬细胞与椎间盘退变的研究进展
朱健,孙凯强,史建刚*
0
(海军军医大学(第二军医大学)长征医院脊柱外科, 上海 200003
*通信作者)
摘要:
椎间盘退变是以椎间盘脱水、细胞外基质降解、蛋白多糖含量下降、胶原类型转变及纤维环外层破裂等为特征的一系列退行性病变,是造成患者运动功能缺失、生活质量低下的主要原因。椎间盘退变的发生率高、致残率高、社会和家庭经济负担大、患者生活质量低下,是全球亟需解决的卫生问题之一。巨噬细胞作为体内主要的吞噬细胞,在机体生长发育的早期就与机体建立了密切联系。研究显示巨噬细胞是唯一的渗透进入封闭髓核的炎症细胞,且巨噬细胞的数量与椎间盘退变的程度呈正相关。研究表明,作为炎症细胞的巨噬细胞可能直接发挥吞噬作用或通过神经-免疫机制协同调节椎间盘的代谢,而巨噬细胞功能失调可引起炎性因子的聚集、趋化和扩散,进而导致椎间盘细胞外基质降解和椎间盘退变。本文通过总结和归纳近年来巨噬细胞参与椎间盘退变相关机制的研究进展,进一步了解椎间盘退变的分子机制,以促进临床治疗模式的改革和进步。
关键词:  椎间盘退变  巨噬细胞  表型转变  迁移  治疗
DOI:10.16781/j.0258-879x.2019.12.1350
投稿时间:2019-03-31修订日期:2019-09-18
基金项目:
Advances on macrophages and intervertebral disc degeneration
ZHU Jian,SUN Kai-qiang,SHI Jian-gang*
(Department of Spine Surgery, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author)
Abstract:
Intervertebral disc degeneration is a series of degenerative diseases characterized by intervertebral disc dehydration, degradation of extracellular matrix, decrease of proteoglycan content, change of collagen type and rupture of outer layer of annulus fibrosis, and it is the main cause of movement function loss and poor quality of life. Due to the high incidence, high disability rate, high society and family economic burden and poor quality of patients' life, intervertebral disc degeneration is one of the urgent health problems to be solved globally. Macrophages, as the main phagocytes in the body, have established a close relationship with the body at the early stage of growth and development. Research has shown that macrophages are the only inflammatory cells infiltrating into the closed nucleus pulposus, and the count of macrophages is positively correlated with the severity of intervertebral disc degeneration. Moreover, evidences have suggested that macrophages, as inflammatory cells, may directly play a role in phagocytosis or synergistically regulate intervertebral disc metabolism through the neuro-immune mechanism, and macrophage dysfunction can cause the aggregation, chemotaxis and diffusion of inflammatory factors, leading to the degradation of extracellular matrix of intervertebral disc and intervertebral disc degeneration. This review summarizes the relevant mechanisms of macrophages involved in intervertebral disc degeneration in recent years, so as to understand the molecular mechanism of intervertebral disc degeneration and promote the reform and progress of clinical treatment mode.
Key words:  intervertebral disc degeneration  macrophages  phenotypic modulation  migration  therapy